What we know – and what we don’t – about Omega-3 fatty acids

Over the past four decades, there have been thousands of studies examining the health benefits of Omega-3 fatty acids – building blocks our bodies use to create cell membranes and maintain the connections between brain cells.

The medical community’s excitement over this nutrient began when observational studies of non-western diets – in Japan and among Eskimos in Greenland, for example – found significantly lower rates of heart disease and other chronic medical conditions.  (Humans can’t produce omega-3 fatty acids, so we must get them by eating fish, walnuts, flaxseed and green vegetables.)

Dozens have studies have identified these types of correlations. But earlier this year, a meta-analysis published in the Journal of the American Medical Association, which included 20 clinical trials involving nearly 70,000 people, concluded omega-3 fatty acids did not prevent heart attacks, strokes or deaths from heart disease.

Proponents of omega-3s point out that the authors of the JAMA analysis used the an especially strict standard to determine statistical significance. (Using the typical standard would have found a 9 percent reduction in cardiac deaths.)

But other systematic reviews – like this one by the Cochrane Collaboration – found it unclear whether omega-3 supplements reduce the risk of cardiac deaths.

So, what’s the bottom line?  This is one case where the evidence is truly unclear. One challenge is that longitudinal diet studies are difficult to perform because there are so many variables in what people eat over long periods of time. The it can be tough to differentiate between omega-3s consumed as part of a diet versus those taken in a supplement.  It is clear that foods like salmon, tuna and green vegetables are good for us – and including them in our diets is a step in the right direction. But we need more evidence to determine their exact effects, and to establish whether it’s worthwhile to take omega-3 supplements.

The facts on Social Security

More than 75 years ago, the U.S. government created Social Security, the federal insurance program that provides benefits to individuals and their families who can no longer work because of disability, retirement or death. The program is complex, and its details are often debated among politicians.

Earlier this year, the Economic Policy Institute and the National Academy of Social Insurance published a guide that explains the facts about the Social Security program to young people. The document includes detailed, evidence-based explanations of Social Security’s history, beneficiaries, financing, and shortfalls. It pulls data from the Office of the Chief Actuary of the Social Security Administration, Congressional Budget Office, the Employee Benefits Research Institute, and the Center for Retirement Research.

Here’s a sampling of interesting facts from the document:

  • In 2012, about 159 million individuals or 94% of the American workforce, worked in Social Security-covered employment. (Those not covered include government employees covered by other insurance programs, farm workers who do not meet minimum work requirements and students.)
  • Approximately 55 million Americans received Social Security benefits in 2011. Seventy percent were retirees; 19 percent were disability beneficiaries and 11 percent were survivors of deceased workers.
  • Without Social Security income, it is estimated that nearly half senior citizens would be living in poverty. Instead, fewer than 10 percent of seniors live in poverty.
  • Because the U.S. population is aging and people are living longer, the Social Security program is projected to run up a deficit. The projected shortfall is 2.67% of taxable earnings over the next 75 years.
  • There are a variety of ways to compensate for the deficit including raising taxes, expanding coverage, investing in equities, increasing the retirement age and reducing cost-of-living increases.

The guide concludes that Social Security fulfills an important need in our society as an insurance program for American workers.  To learn more about Social Security benefits and about how your payroll taxes are used, it’s worth checking out this evidence-based document.

Coffee update: It’s actually good for you

Here at EBL, we’ve written about coffee before. But given that more than 60 percent of Americans consume coffee on a daily basis, we think it’s an important to understand its effects. We were excited to come across a new systematic review on America’s favorite drink and its relationship to heart failure.

The review included five prospective studies of more than 140,000 people in total measuring the relationship between regular coffee consumption and the risk of heart failure. Across all of the studies, more than 6,500 participants suffered heart failure.

According to the analysis, consuming a moderate amount of coffee was inversely related to risk of heart failure: people who drank four servings of coffee a day had the smallest risk of heart failure.  Those who drank significantly more or less than four servings a day were found to have a higher risk heart failure. The review found there were no variance between men and women, or for participants who had a history of heart attack or diabetes.

Clearly, there is more to this story, and further study is warranted on the health benefits of coffee are warranted. But to date, the evidence indicates that drinking coffee regularly isn’t risky and may actually protect you against heart failure.

The science of political campaigns, Part 2

Next month, President Barack Obama and Republican Presidential Candidate Mitt Romney will face off on national television on four separate occasions to share their ideas for governing America and explain why voters should chose them.

While it’s not clear how many Americans make their voting decisions based on the debates, we do know they are an important part of the campaign. So I was thrilled to find some evidence on how to consider the candidates responses critically.

Todd Rogers, a behavioral psychologist at Harvard University, is among a growing group of researchers applying social science to issues effecting political campaigns. (We’ve written about his work on get-out-the-vote phone calls.)  He wanted to address the issue of how candidates respond when get asked a question that they don’t want to answer – and whether the public notices when politicians dodge a question by talking about a different topic instead.

Rogers and his colleague Michael Norton, an associate professor at the Harvard Business School, designed a study to determine under what conditions people can get away with dodging a question, and under what conditions listeners can detect what’s happening.

In their study, published in the Journal of Experimental Psychology, they recorded a speaker answering a question about universal healthcare. Then they paired that answer with three separate questions: the correction question about health care, one about illegal drug use and another about terrorism.  They showed the three question-and-answer pairings to separate groups of people and asked them to rate the truthfulness of the speaker.

Their research found that when the question and answer sounded somewhat similar – such as in the case where the speaker was asked about drug use but responded about healthcare –  the audience rate the speaker as trustworthy.  (In fact, most of the people who head the answer about illegal drug use couldn’t even remember the question.) But when the answer was very clearly addressing a different topic – such as when the speaker was asked about health care but responded about terrorism – the audience detected the dodge.

In another part of the study, Rogers and Norton used the same questions and answers, but posted the question on the screen in for some viewers. They found  viewers who saw the question posted on the screen while the speaker answered were more than twice as likely to detect a dodge, even in subtle cases.

Rogers advocates for posting the questions on the screen during the presidential candidates debates, although he concedes it’s unlikely to happen this year.

You can hear an interview with Rogers  and learn about other research on political campaigning in last week’s episode of NPR’s Science Friday.

Can we fend off chronic disease? The evidence says yes

We have all heard that physical fitness is an important factor in health, but how important a factor?  And is it ever too late to get fit?

A study published earlier last month in the Archives of Internal Medicine suggests that becoming fit in middle age, even if you haven’t previously exercised, can stave off illness later in life.

In the study, researchers collected medical records for more than 18,000 healthy middle-aged men and women who’d visited the Cooper Institute in Dallas, Texas for a check-up since 1970. Each subject took a treadmill test to determine their aerobic fitness at their first check-up. Then the researchers checked their Medicare records from 1999 through 2009.

The study found that people who were least fit at the time of their initial check-up were the most likely to developed chronic conditions such as heart disease and cancer early in the aging process. Those who were most in middle-age developed the same conditions, but significantly later in life compared to the less fit.

The take-home message of this study actually parallels a lesson shared in Karl’s book 30 Lessons for Living, which shares advice from America’s elders. The lesson is: It’s not dying you should worry about – it’s chronic disease.

This study provides evidence that you can actually do something to help prevent chronic disease later in life – exercise!

The study is backed up by several systematic reviews. One published in the Journal of Science and Medicine in Sport found physical activity helps prevent heart disease, cancer and diabetes. Another published in Obesity Reviews found individual who are overweight but have good aerobic fitness are at lower risk of cardiovascular disease compared with individuals with normal weight and poor fitness.

The bottom line: Physical fitness can help you lead a healthier, happier life no matter what your age.

Is organic food really better for you?

Over the past decade, our society is growing increasingly aware of our reliance on chemical products and their impacts on the environment and our health. So last week, a new study by Stanford University researchers on the benefits of organic foods received a lot of media coverage.

The systematic review, published in the Annals of Internal Medicine, examined 240 studies organic and non-organic fruits, vegetables, grains, meat, poultry eggs and milk — 17 studies of humans and 223 studies of nutrient and contaminant levels.

It found that more one-third of conventional produce had detectable pesticide residues, compared with 7 percent of organic produce samples. And it found organic meats were one-third less likely to carry bacteria resistant to antibiotics than conventionally produced meat.

But the study also found that organic foods, on the whole, don’t contain any more vitamins or nutrients than conventional foods.

It’s good to have a wide-ranging review of organic foods. Even more interesting is the media coverage of the study. Some new stories, like this one from the Guardian, have focused on the lack of a difference in nutrient levels. Other news coverage has pointed out that the purpose of purchasing organic foods is to avoid pesticide use because of its impact on human health and the environment.

The bottom line: it’s important to understand all of the findings in a study. Sometimes, that requires looking past the headlines in media outlets so that you can get the full story.

Football frets: The evidence on repetitive head injuries

With football season underway, many Americans are spending their weekends cheering on their favorite teams at stadiums and tuning in to watch televised games.  Personally, I enjoy following my college football team. But I always feel a sense of dread when a player takes an especially hard hit.

It turns out, those repeated hits add up to some real neurological problems for football players.

A study published this week in the journal Neurology followed nearly 3,500 football players who played at least five seasons in the N.F.L. from 1959 to 1988.

Over the course of the study, 334 of the players died. When researchers from the National Institute of Occupational Safety and Health reviewed their death certificates, they found Alzheimer’s disease was an factor in seven of the deaths and Lou Gehrig’s disease was a factor in seven others. These rates are more than three times what you would expect to see in the normal population.

This new study is part of a growing body of research on the neurological repercussions of repeated head injuries. Another study published earlier this year found repetitive head impacts over the course of a single season may negatively impact learning in some collegiate athletes.

And a center at the Boston University School of Medicine has documented evidence of a condition called Chronic Traumatic Encephalopathy, or CTW, a progressive degenerative disease of the brain found in people with a history of repetitive brain trauma.

The N.F.L. is investing in more research. This week, the organization donated $30 million to the National Institutes of Health for research on the connection between brain injuries and long-term disorders. That’s a good thing, because this is one topic we need more evidence on.

Slimming it down? New evidence on low-calorie diets

Over the past few years, you may have heard the buzz about the potential for a low-calorie diet to prolong life and prevent chronic medical conditions like heart disease and cancer.

While the concept of restricting calories has been around for decades, a longitudinal study of monkeys published in 2009 seemed to provide definitive evidence that eating less was good for you. The study by researchers at the University of Wisconsin found a diet of moderate caloric restrictions over 20 years lowered the incidence of aging-related deaths and reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy.

But last week, a new longitudinal study of different species of monkey raised questions about the idea of restricting calories to improve health. The study included 121 monkeys split into two groups. The experimental group was fed 30 percent fewer calories than the control group.

In the study published last week, which was sponsored by the National Institute on Aging, the monkeys on restricted diets did not live any longer than those with normal diets. Rates of cancer and heart disease were the same for monkeys on restricted diets and normal diets. While some groups of monkeys on restricted diets had lower levels of cholesterol, blood sugar and triglycerides, they still did not live longer than the monkeys who ate normally.

The study is interesting from a health perspective because it raises questions about the notion of restricting calories to improve health. But it’s also a prime example of why it’s important to collect data from more than one study.

“This shows the importance of replication in science,” Steven Austad, interim director of the Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center, told the New York Times. Austad, who was not involved in either study, also explained that the first study was not as conclusive as portrayed in the media.

The take home message: It’s important to collect evidence from multiple studies before drawing conclusions, even when the data seems extremely convincing.

What we know about car seats and how kids use them

We have known for a long time that car seats save children’s lives. But even with that knowledge, do parents and caregivers use them appropriately?

A new study by researchers at University of Michigan found that while most people use child restraints properly, many do not. The researchers analyzed data on more than 21,000 children observed in cars at gas stations, fast-food restaurants, recreation centers and child care centers from 2007 to 2009 using guidelines from the American Academy of Pediatrics.

They found 21  percent of children ages 4 and younger were not following the recommendations for sitting in car seats. Thirty-three percent of 4- and 5-year olds and 66 percent of 6- and 7-year-olds were not following the recommendations for using car seats or booster seats. And – the most precarious finding – 11 percent of children were not wearing seat belts or sitting in car seats at all. Children were especially likely to be completely unrestrained if they were driving with an adult who wasn’t wearing a seat belt or if there were four or more children in the car.

While the evidence on kids using car seats is not encouraging, there are some intervention programs proven to increase the use of child safety seats. One systematic review found strong evidence that child safety seat laws increase the use of safety seats. Programs that combine education with distribution of car seats, incentives for installing car seats correctly and stepped up enforcement of laws also increase the use of car seats.

The bottom line: Car seats help save kids lives. It’s important to use them as recommended by the American Academy of Pediatrics.

How to remind people to take their medicine

The intersection of medicine and technology is always interesting – with so many opportunities for improving health and wellness.  But it can be hard to know what really works.

A new systematic review is shedding some light on the subject. The Cochrane Collaboration reviewed two studies of nearly 1,000 HIV-positive adults in Kenya taking antiretroviral therapy, which requires daily doses of oral medicine.

They found that patients receiving text messages reminding them to take their medications were less likely to miss doses. One of the studies also demonstrated that patients receiving weekly text-messages were at lower risk of missing medicine doses compared with patients receiving daily messages.

Geri Gay, a Cornell communications professor focused on interactive communication technologies, says these type of messages are just a start.

“There is an enormous potential to use mobile technologies to help us change what we think and do,” she said. “These  mobile tools can not only tailor and deliver health messages for particular times and locations but can also provide feedback and social support.”

While the review found some positive results, it only included two trials with adult patients in Kenya. The authors concluded researchers needed to study whether texting helps adolescents remember to take their medicines, and whether this type of intervention works higher-income countries.

While the results are preliminary, this type of work paves the way for additional research that can tell us even more about using technology to improve health outcomes across the globe.

New evidence: Vitamin D helps prevent falls

Vitamin D is one of those supplements that makes it into the news media frequently. Here on EBL, we’ve written before about the U.S. Institute of Medicine’s recommendations on Vitamin D intake.

Now there is a new recommendation that taking Vitamin D supplements can help prevent falls in people over 65 years old with a higher risk of falling.

In a review of nine separate studies, the United States Preventative Services Task Force came to the conclusion a daily dose of 800 international units reduced the risk of falling by about 17 percent, compared with those who did not take the vitamin.

“The exact mechanism is not known, but it seems to help muscle strength and balance,” Dr. Al Siu, vice chairman of the task force and chairman of the geriatrics and palliative medicine department at Mount Sinai School of Medicine, told the New York Times.

The panel also made two other recommendations.  Doctors should do a comprehensive assessment of patients’ risk of falling – including asking about falling history and observing patients stand up and walk – to identify those at higher risk. And patients’ should exercise to improve strength and balance.

Falls are the leading cause of injury in adults 65 and older. While there’s no sure-fire way to prevent them, we have evidence that some interventions do work. That’s important information for all of us to know.

Evidence-based Olympics, Part II: The facts on fitness products

We’ve all seen the advertisements of the sweaty, exhausted athlete pausing to take a sip of a brightly-colored drink and then going on to score the winning goal or set a personal record. Magazines and web sites – especially in these days when Olympic athletes dominate the news – are filled with fitness products that supposedly make you perform better or recovery more quickly.  But are any of those claims true?

A group of researchers at the University of Oxford set out to answer that exact question. They analyzed magazine advertisements and web sites of 104 different fitness products looking for real evidence behind their claims. Then they wrote to manufacturers of fitness products asking for references to research that backed up their claims.

But their study did not find much credible evidence. More than half of the web sites they reviewed did not provide any references. They did find a total of 146 specific references to study, but they were only able to find 76 studies to review.

None of the studies they found were systematic reviews. Eighty-four percent were judged to be of high risk-bias, and only 58 percent used randomization. In total, only three of the studies were judged to be high quality.

The study was thoroughly reported on in the New York Times, along with responses from beverage manufacturers and from health and nutrition experts not involved in the study.

Politics aside, there is a clear lack of evidence about whether performance-enhancing products really work.

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